look for several patterns in the file and delete the line if the pattern matches

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For ex, a file contain contents:

10.45.56.84 raj
10.49.31.81 mum
10.49.31.86 mum
10.81.51.92 guj
10.45.56.116 raj
10.45.56.84 raj

I want to search 10.45.56.84 and 10.81.51.92 in the above file and delete line if pattern matches.

Also i want to do this in single command.


Another solution:

 awk '!/10.45.56.84|10.81.51.92/' file